Endocrine Abstracts

Background: Pituitary apoplexy is a rare clinical syndrome due to abrupt hemorrhaging and/or infarction of the pituitary gland, generally within a pituitary adenoma. The outcome of acute apoplexy is variable and difficult to predict. This explains why the optimal management of acute pituitary apoplexy remains controversial. The aim of our study was to investigate the clinical, hormonal and radiological characteristics of pituitary apoplexy and to determine treatment outcomes.<...

A 38-year-old woman presented with symptoms suggesting Cushing’s syndrome. She has a history of surgery of mature ovarian teratoma (hysterectomy, ovarectomy) associated to radio and chemotherapy 15 years ago. The malignant teratoma relaps with hepatic and grelic metastases, and was unresectable. Main complaints were weight gain with centripetal fat distribution, muscle weakness, melanodermia and purpule striae on the skin of the abdomen, thighs, breasts and arms....

Introduction: Fanconi anemia (FA) is an autosomal recessive disease associated with chromosomal instability, it is marked by phenotypic heterogeneity. Patients with FS often exhibit growth retardation due to complex factors such as hypophosphatemia, metabolic acidosis, disturbed vitamin D metabolism. On the other hand, endocrinopathies are a common feature of FA specially such as Growth hormone deficiency (GHD). We report here two cases of Fanconi disease associated to GH defi...

Introduction: Although Graves’ disease is often accompanied by other autoimmune diseases, only a few cases of Graves’ disease accompanied by pheochromocytoma have been described.Herein we report a rare case of coexisting Graves’ disease and pheochromocytoma.Observation: A 50-year-old male patient was referred to our department for the evaluation of right adrenal incidentaloma of 80*66 mm. He had a history of coronary...

Introduction: Widespread use of abdominal imaging has led to the identification of an increasing number of adrenal incidentalomas (AI) in the last decades. Causes of these adrenal masses are multiple.Aim: The aim of this study was to investigate the clinical and hormonal characteristics of AI.Materials and methods: The study was a retrospective monocentric analysis of 44 patients with AI who underwent radiographic and endocrine eva...

Introduction: Cardiothyreosis (CT) is the most frequent and dangerous complication of hyperthyroidism (HT). It is defined as an association of HT with severe heart abnormalities such as: rhythmic troubles, heart and/or coronary insufficiency. The aim of our study was to describe the frequency and the clinical characteristics of CT in Graves’ disease (GD).Methods: Patients with GD were enrolled into a retrospective study. The prevalence and the clini...

Introduction: Graves’ ophthalmopathy (GO) is an autoimmune disorder affecting the retro-orbital tissues. It represents the main extra- thyroidal expression of Graves’ disease (GD). Its onset and progression are influenced by several factors that are potentially modifiable. The aim of this study was to identify risk factors for severe GO.Methods: Patients with GD were enrolled into a retrospective study. We compared possible risk factors and var...

The Miller-McKusick-Malvaux (3M) syndrome is a primordial growth disorder characterized by low birth weight, reduced birth length, severe postnatal growth restriction, a spectrum of skeletal anomalies, facial dysmorphism and normal intelligence. Mutations in the CUL7 gene (6p21.1) are most often responsible for 3M syndrome (67% of cases). Other causal mutations include those in the OBSL1 gene (2q35), in 28% of cases, or the CCDC8 gene (19q13.33), in ...